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Alicanto Antibody Discovery – Diversity

Alicanto Antibody Discovery – Diversity

Alicanto® is Abterra Biosciences' proprietary antibody discovery platform that mines the entire immune response to identify diverse, functional antibodies. For an overview of the proteogenomic process, read more about Alicanto®. Alicanto benefits include: Full...

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Antibody Reference Guide

Antibody Reference Guide

We developed a one-sheet antibody reference that is handy for antibody-related work. We refer to it often to remind ourselves of the major antibody isotypes, antibody fragments, and purification strategies, as well as antibody development processes. Below we outline...

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BCR Repertoire Sequencing: Error Correction

BCR Repertoire Sequencing: Error Correction

Sequencing errors: where do they come from?Immune repertoire sequencing (Rep-seq) allows us to deconvolute the population of antibody sequences that comprise an individual’s B-cell response. While antibody repertoire diversity is known to be vast, errors can cause a...

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VHH Discovery By Serum Proteomic Analysis

VHH Discovery By Serum Proteomic Analysis

Llama VHH discovery from serumCamelids, such as llamas and alpacas, naturally produce both conventional antibodies and heavy-chain only antibodies (HCAbs)(1). The antigen-binding domain of the HCAb, called the VHH or nanobody, is comprised of a single polypeptide...

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I/L Determination in De Novo Antibody Sequencing

I/L Determination in De Novo Antibody Sequencing

Isoleucine and leucine determinationDe novo antibody sequencing by tandem mass spectrometry(MS/MS) uses the differences in mass of different amino acids to accurately determine the correct sequence. Distinguishing between isoleucine (Ile) and leucine (Leu) residues is...

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Constructing an Accurate Antibody Repertoire

Constructing an Accurate Antibody Repertoire

What is an antibody repertoire?The immune repertoire is the collection of unique immunoglobulin and T-cell receptor sequences present in an individual at a particular time. At Digital Proteomics we focus primarily on the immunoglobulin, or B-cell receptor repertoires...

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From RNA to Sequencing: QC Matters

From RNA to Sequencing: QC Matters

Sequencing the immunoglobulin (Ig) repertoire provides us with important information on the adaptive immune response, and can help with the development of diagnostic and therapeutic applications. A single human can have an estimated 10¹¹ B cells with millions of...

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