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Antibody Protein Sequencing with Valens

De Novo Antibody Sequencing

Lost your hybridoma? For over a decade, our Valens™ platform has performed antibody protein sequencing to determine the primary amino acid sequence of monoclonal antibodies directly from the protein. Using mass spectrometry together with our patented spectral networking approach, Valens™ recovers full-length amino acid for heavy and light chains.

Valens antibody protein sequencing workflow from mAb to sequences

Isoleucine & Leucine Determination

Valens™ now supports CLIP™, a Bayesian approach to isoleucine and leucine determination.

Isoleucine and leucine are isomers, having identical mass but different structures. CLIP™ uses side-chain fragmentation of isoleucine and leucine to determine the correct amino acid during de novo antibody sequencing.

 

** CLIP is included for FREE with every project  **

Isoleucine leucine structures
Partnership between Abterra Bio and LakePharma on Valens

Antibody Sequencing & Expression

Material Requirements – 50ug of purified monoclonal antibody

Turnaround time – 3 weeks to sequence (expedited available)

Work performed 100% in the USA

We now offer our unique service in partnership with Antibody Design Laboratories.  Transient production in a variety of formats and volumes available.

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Resources & Publications

Valens builds on over a decade of algorithm development including ideas invented at the University of California – San Diego Center for Computational Mass Spectrometry. For background on our methods check out these publications:

We recently summarized the approaches to de novo antibody sequencing in a blog post.