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Catch up on recent literature showcasing our solutions in action!

We have compiled all of our white papers and case studies on one page for your convenience.

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Service Literature


Antibody Protein Sequencing using Mass Spectrometry

Polyclonal Sequencing

Polyclonal Antibody Sequencing using Mass Spectrometry


Antibody Sequencing from Patient Serum


VHH Antibody Discovery


Bulk BCR Repertoire Sequencing and Analysis


High-throughput Hybridoma Sequencing using NGS


White Papers and Case Studies


  • Alicanto Case Study: Discovery of high affinity anti-beta galactosidase rabbit antibodies
  • Alicanto Case Study: Diverse VHH discovery from serum

Valens and Quorum Cloud

  • Valens with CLIP Case Study: Confirmation of Leucine or Isoleucine presence in de novo antibody sequencing
  • Molecular Networks: A deep dive into the world of small molecules


  • Clonal Hit-Expansion Case Study: NGS repertoires extend hits by finding more members of the same clone (Infographic)
  • Enrichment of Memory B Cells for Antibody Discovery and Next-Generation Sequencing (Collaboration with Nanocellect Biomedical)


Publications by Abterra Bio founders and team members include:

      Chen, Elaine, et al. “Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes.” Cell reports (2023): 42, 4 (PubMed: 37029928)

      Tomasina, Florencia, et al. “De novo sequencing and construction of a unique antibody for the recognition of alternative conformations of cytochrome c in cells.” PNAS (2022): 119, 47 (PubMed: 36378644)

      Deszynski, Piotr, et al. “INDI-integrated nanobody database for immunoinformatics.” Nucleic Acids Res (2022): 50 (PubMed: 34747487)

      Gilchuk, Pavlo, et al. “Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma.” Frontiers in Immunology (2021): 2782. (Frontiers Immunol: 706757)

      Bonissone SR, Lima T, Harris K, Davison L, Avanzino B, Trinklein N, et al. Serum Proteomics Expands on High-Affinity Antibodies in Immunized Rabbits Than Deep B-Cell Repertoire Sequencing Alone. BioRxiv (2020) 833871. doi: 10.1101/833871. (BioRxiv: 833871)

      Cha, SW, Bonissone, S, Na, S, Pevzner, PA, Bafna, V (2017). The Antibody Repertoire of Colorectal Cancer. Mol Cell Proteomics, 16, 12:2111-2124. (PubMed: 29046389)

      Bonissone, Stefano R., and Pavel A. Pevzner. “Immunoglobulin classification using the colored antibody graph.” Journal of Computational Biology 23.6 (2016): 483-494. (PubMed: 27149636)

      Y. Safonova, S. Bonissone, E. Kurpilyansky, E. Starostina, A. Lapidus, J. Stinson, L. DePalatis, W. Sandoval, J. Lill, and P. A. Pevzner. IgRepertoire Constructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis. Bioinformatics, 31(12):53–61, Jun (2015) (PubMed: 26072509)

      S. R. Bonissone, P. A. Pevzner, Research in Computational Molecular Biology, 44–59 (2015). (Springer)

      Guthals, et al. (2012). Shotgun protein sequencing with meta-contig assembly. Mol Cell Proteomics, 11, 10:1084-96. (PubMed: 22798278)

      Castellana, NE, McCutcheon, K, Pham, VC, Harden, K, Nguyen, A, Young, J, Adams, C, Schroeder, K, Arnott, D, Bafna, V, Grogan, JL, Lill, JR (2011). Resurrection of a clinical antibody: template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin- antibody. Proteomics, 11, 3:395-405. (PubMed: 21268269) 

      Castellana, NE, et al. (2010). Template proteogenomics: sequencing whole proteins using an imperfect database. Mol Cell Proteomics, 9, 6:1260-70. (PubMed: 20164058)

      Bandeira, N, Pham, V, Pevzner, P, Arnott, D, Lill, JR (2008). Automated de novo protein sequencing of monoclonal antibodies. Nat. Biotechnol., 26, 12:1336-8. (PubMed: 19060866)

      Bandeira, N, et al. (2007). Shotgun protein sequencing: assembly of peptide tandem mass spectra from mixtures of modified proteins. Mol Cell Proteomics, 6, 7:1123-34. (PubMed: 17446555)

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