De Novo Antibody Sequencing Case Study
Abterra Bio uses bioinformatics and mass spectrometry to reconstructs the full amino acid sequence of both antibody chains. We’ve successfully sequenced human, mouse, rat, hamster, rabbit, and llama antibodies. This approach can be applied across any species and isotype, including IgG’s and IgM’s.
Contact us to learn more about how our Valens™ de novo antibody sequencing can recover the full antibody sequence when no source cell is available!
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For 100% sequence accuracy, antibody sequencing experience matters. Read our blog post to understand more about our service and why you would need de novo sequencing.
VHH Discovery with Alicanto versus Phage Display
Project Summary Camelids such as llamas and alpacas produce conventional antibodies as well as heavy-chain only antibodies (HCAbs) from which the small, stable, antigen-binding domain (VHH) can be extracted. Target-specific VHHs can be identified from immunized...
Abterra Bio awarded $1.8M NIH SBIR to extend antibody repertoire analysis software, REPTOR
Next-generation sequencing is a valuable readout for antibody discovery campaigns, but current software does not address the real pain points of analysis. Abterra Biosciences has developed Reptor software to enable visualization and interrogation of large-scale...
Limit of Detection – Serum Antibody Analysis
In this blog post, we evaluate the limit of detection for serum antibody analysis achieved by Alicanto using spike ins.