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BCR Repertoire Sequencing: Error Correction

BCR Repertoire Sequencing: Error Correction

BCR Repertoire Sequencing: Error Correction Sequencing errors: where do they come from? Immune repertoire sequencing (Rep-seq) allows us to deconvolute the population of antibody sequences that comprise an individual’s B-cell response. While antibody repertoire...
VHH Discovery By Serum Proteomic Analysis

VHH Discovery By Serum Proteomic Analysis

Llama VHH discovery from serum Camelids, such as llamas and alpacas, naturally produce both conventional antibodies and heavy-chain only antibodies (HCAbs)(1). The antigen-binding domain of the HCAb, called the VHH or nanobody, is comprised of a single polypeptide...
I/L Determination in De Novo Antibody Sequencing

I/L Determination in De Novo Antibody Sequencing

I/L Determination in De Novo Antibody Sequencing Isoleucine and leucine determination De novo antibody sequencing by tandem mass spectrometry(MS/MS) uses the differences in mass of different amino acids to accurately determine the correct sequence. Distinguishing...
Constructing an Accurate Antibody Repertoire

Constructing an Accurate Antibody Repertoire

Constructing an Accurate Antibody Repertoire What is an antibody repertoire? The immune repertoire is the collection of unique immunoglobulin and T-cell receptor sequences present in an individual at a particular time. At Digital Proteomics we focus primarily on the...
From RNA to Sequencing: QC Matters

From RNA to Sequencing: QC Matters

Sequencing the immunoglobulin (Ig) repertoire provides us with important information on the adaptive immune response, and can help with the development of diagnostic and therapeutic applications. A single human can have an estimated 10¹¹ B cells with millions of...

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