Griffin Overview
Griffin for Polyclonal Antibody Sequencing
- Are you suffering from batch-to-batch variability in your polyclonal antibodies?
- Are you having trouble sourcing donors with the needed reactivity?
- Sick of poorly characterized products in your assays?
Griffin brings your polyclonal antibody into the bioreactor
A 3 stage process de-risks your project with Go/No Go decision points
STAGE 1
Assess clonality to determine complexity and specificities.
STAGE 2
Full-length antibody sequencing and assembly.
STAGE 3
Expression and validation
Curious to see what’s in your polyclonal?
Griffin Deliverables
Sequences – Full sequence information for all hits identified by Griffin.
Binding report – Binding evaluation of all sequences.
Expressed antibodies – Transient production of candidates.
Get In Touch
Tell Us About Your Project.
Need more information? We’re here to answer any questions you have.
Resources and Publications
Alicanto® integrates next-generation sequencing analysis of antibody repertoires with computational mass spectrometry measurements of antibody proteins. The early algorithmic foundation for Alicanto® was developed at the Computer Science and Engineering Department at the University of California – San Diego.
Publications by Abterra Bio founders and team members include:
- Safonova, et al. (2015). IgRepertoire Constructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis. Bioinformatics, 31, 12:i53-61.
- Cha, SW, Bonissone, S, Na, S, Pevzner, PA, Bafna, V (2017). The Antibody Repertoire of Colorectal Cancer. Mol Cell Proteomics, 16, 12:2111-2124.
- Bonissone, SR, Pevzner, PA (2016). Immunoglobulin Classification Using the Colored Antibody Graph. J Comput Biol, 23, 6:483-94.