Mar 3, 2020 | Science, Services
Next Generation Sequencing-Enhanced Antibody Discovery Using Reptor for NGS-enhanced antibody discovery Traditional antibody discovery methods, such as hybridoma and phage display, as well as newer single cell screening methods, capture only a small portion of the...
Nov 5, 2019 | Science, Services
BCR Repertoire Sequencing: Error Correction Sequencing errors: where do they come from? Immune repertoire sequencing (Rep-seq) allows us to deconvolute the population of antibody sequences that comprise an individual’s B-cell response. While antibody repertoire...
Oct 22, 2019 | Science, Services
VHH Discovery By Serum Proteomic Analysis Llama VHH discovery from serum Camelids, such as llamas and alpacas, naturally produce both conventional antibodies and heavy-chain only antibodies (HCAbs)(1). The antigen-binding domain of the HCAb, called the VHH or...
Jul 1, 2019 | Science, Services
I/L Determination in De Novo Antibody Sequencing Isoleucine and leucine determination De novo antibody sequencing by tandem mass spectrometry(MS/MS) uses the differences in mass of different amino acids to accurately determine the correct sequence. Distinguishing...
May 22, 2019 | Science, Services
Single-molecule Ig Repertoire Sequencing from Lama glama In recent years, camelids have become more than hearty travel companions due to their unconventional adaptive immune systems. Conventional IgG antibodies are tetrameric molecules comprised of two heavy chains...
Mar 5, 2019 | Science, Services
Constructing an Accurate Antibody Repertoire What is an antibody repertoire? The immune repertoire is the collection of unique immunoglobulin and T-cell receptor sequences present in an individual at a particular time. At Digital Proteomics we focus primarily on the...
