Scientific News
Advantages of High-Throughput Hybridoma Sequencing with NGS
Having a diverse collection of leads at the beginning of your antibody development campaign is critical for downstream success. As we know well, the immune response to immunization often focuses on a small number of antibody families with highly similar CDR3s which...
Why Sequence My Antibody Protein?
Over the past decade of sequencing thousands of antibodies, we've discovered the top reasons to sequence your antibody protein.Top reasons to sequence my antibody 1. To protect my intellectual property through patents for regulatory application and antibody...
Case Study: Alicanto Discovers High Affinity Rabbit Antibodies to Detect Neurofibromin
Researchers at Infixion Bioscience are on a mission to develop new therapeutics for the “orphan disease” neurofibromatosis type 1, which is diagnosed at a rate 1 in 3000 live births, impacting millions across the globe. Neurofibromatosis type 1 is a genetic disorder...
Customer Spotlight: Dr. Matthew Burchill
Valens™ Rescues Antibody for Liver Disease ResearchDr. Matthew Burchill explains how Abterra Bio's technology, Valens rescued his antibody and enabled him to continue his research in chronic liver disease. "The sequencing provided is instrumental to our work as the...
Multi-Species Antibody Repertoire Comparison
A decade ago, in vivo antibody discovery relied heavily on wild-type mice. Today, it’s not uncommon to generate antibodies using a petting zoo of animals including chicken, goat, rabbit, llamas, alpacas, and humanized rodents. The immune responses of these animals...
NGS During The Hybridoma Generation Process
Next-generation sequencing (NGS) has allowed for unprecedented insights into patterns of the immune response. It can enable high-throughput sequencing of hybridomas as we have discussed in NGS-Enhanced antibody discovery blog post and resource pages. NGS can provide a...
De Novo Antibody Sequencing Case Study
Abterra Bio uses bioinformatics and mass spectrometry to reconstructs the full amino acid sequence of both antibody chains. We’ve successfully sequenced human, mouse, rat, hamster, rabbit, and llama antibodies. This approach can be applied across any species and...
New Publication Reveals Ebolavirus-Neutralizing Monoclonal Antibodies
Abterra Biosciences, together with VUMC Vaccine Center, Mapp Bio, PNNL, UTMB Health, Ragon Institute, Integral Molecular, and La Jolla Institute, recently published a paper describing the discovery of Ebolavirus-neutralizing antibodies from convalescent plasma.Read...
Immune Repertoire Sequencing in Human
Immune repertoire sequencing enables deeper understanding of the adaptive immune response [1]. Abterra Biosciences has developed Reptor™, a flexible immune repertoire sequencing and analysis service. In this study, we analyzed the B-cell receptor (BCR) repertoire...
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