Scientific News
Can You Sequence an Antibody?
Dec 19, 2025 | Products, Science, Services
What does it mean to sequence an antibody?Antibodies are tetrameric proteins comprised of two identical heavy chains and two identical light chains. One naturally occurring exception to this is the heavy chain-only antibodies produced by camelids and cartilaginous...
FASTA2AIRR: comparing human and humanized antibodies
Nov 23, 2025 | Science, Services
Fasta2airr is a free web app for converting antibody sequences into annotated AIRR-Seq files. Converting sequences into this open format is an essential step in antibody repertoire analysis. Among other antibody meta data the AIRR-Seq file contains: Germline gene...
VHH De Novo Antibody Sequencing
Sep 17, 2025 | News, Science, Services
VHHs are 15kDa proteins that represent the antigen binding portion of heavy chain-only antibodies (HCAb) from llamas and alpacas. Their small size and stability make them ideal components of therapeutics such as bispecific antibodies or CAR-T therapies. In addition,...
Polyclonal Antibody Sequencing in Camelids
Aug 19, 2025 | Science, Services
Serum contains circulating antibodies with unique functional properties. This fundamental fact is why we choose to mine the serum over cells - despite being more challenging. Here we compare the two approaches for polyclonal antibody sequencing available at Abterra...
Rabbit Polyclonal Antibody Sequencing for Neurodegenerative Disease Research
Jul 25, 2025 | Products, Science, Services
Rabbit polyclonal antibodies are commonly used reagents across biotech and academia. As of 2024, 43% of commercial catalog antibodies are polyclonals, and 66% of those are rabbit derived. Hyperimmunized rabbits consistently generate high affinity, target-specific...
De Novo Antibody Sequencing NISTmAb with Post-Translational Modification Detection
Jun 26, 2025 | Science, Services
Protein sequencing has been possible for 75 years with Edman degradation, but over the past decade, mass spectrometry (MS)-based sequencing has become the dominant approach for antibodies. The general strategy is to digest antibody proteins into short peptides using...
Monoclonal versus Polyclonal Antibody Sequencing
Jun 15, 2025 | Products, Science, Services
Antibody reagents used in biomedical research and diagnostics assays fall into two large categories: monoclonals and polyclonals. For high-quality reagents, an antibody needs to demonstrate specific reactivity in its intended assay, and maintain consistency across...
Polyclonal Antibody Sequencing Methods
Jun 1, 2025 | Products, Science, Services
Polyclonal Antibody Sequencing Methods Polyclonal antibody sequencing is a powerful tool for understanding the humoral immune response.1 Two primary approaches exist: Proteogenomic Polyclonal Antibody Sequencing and De Novo Polyclonal Antibody Sequencing. This guide...
Griffin: Accessing functional antibodies from serum without B cells
May 20, 2025 | Science, Services
Griffin is a platform for sequencing polyclonal antibodies using mass spectrometry. Since 2009, Abterra Biosciences founders and employees have been developing novel methods for sequencing antibody proteins directly. Our monoclonal antibody sequencing service,...
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