Why Sequence My Antibody Protein?
Over the past decade of sequencing thousands of antibodies, we’ve discovered the top reasons to sequence your antibody protein.
Top reasons to sequence my antibody
1. To protect my intellectual property through patents for regulatory application and antibody production.
2. To secure my antibodies in case my hybridomas stop producing or my freezers fail. At Abterra Bio, we have worked on many projects over the years to rescue proteins for our clients. (or any biological failures). We can help you prepare for the worst by sequencing the hybridomas using next-generation sequencing , or help you recover from disaster by sequencing the antibody protein.
3. To ensure quality and consistency of my research. I can produce my antibody recombinantly once I have the sequence, ensuring the same antibody is produced in every batch.
Valens™ is a mass spectrometry-powered service to sequence and provide direct information about the antibody protein. We offer two services using Valens™; antibody protein sequencing to recover the full antibody sequence when no source cell is available and antibody sequence confirmation to determine if the produced antibody matches the intended gene sequence.
We summarized the methods for antibody protein sequencing in a related blog post.
Important considerations when choosing an antibody sequencing partner:
- Experience – we have over 10 years of antibody protein sequencing, and sequenced thousands of hybridomas, so we know how to sequence an antibody!
- Location – all work is performed in the US.
- Flexibility – we’ve sequenced samples with as little as 20 ug, low purity supernatant samples, and sample with conjugates.
Tell Us About Your Project
Related Posts
VHH De Novo Antibody Sequencing
VHHs are 15kDa proteins that represent the antigen binding portion of heavy chain-only antibodies (HCAb) from llamas and alpacas. Their small size and stability make them ideal components of therapeutics such as bispecific antibodies or CAR-T therapies. In addition,...
Polyclonal Antibody Sequencing in Camelids
Serum contains circulating antibodies with unique functional properties. This fundamental fact is why we choose to mine the serum over cells - despite being more challenging. Here we compare the two approaches for polyclonal antibody sequencing available at Abterra...
Rabbit Polyclonal Antibody Sequencing for Neurodegenerative Disease Research
Rabbit polyclonal antibodies are commonly used reagents across biotech and academia. As of 2024, 43% of commercial catalog antibodies are polyclonals, and 66% of those are rabbit derived. Hyperimmunized rabbits consistently generate high affinity, target-specific...