VHH Antibody Discovery from Serum
Custom VHH antibody discovery using Alicanto®
- An approach that doesn’t use phage or yeast display
- Directly capture the natural diversity of the immune response
- Sequences for all hits
- Quick go or no-go decision upfront
- No more panning!
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Higher Hit Rate
- We enrich for the desired VHH antibodies at the earliest stages of the process, which allows us to avoid wasting time on antibodies that don’t have the desired specificity.
In Vivo Engineering
- We deliver all related VHH sequences to validated hits which allows you to discover new candidates with potentially different profiles of affinity, immunogenicity, and sequence liabilities.
VHH Antibody Discovery Process
At least 10 diverse candidate sequences selected by Alicanto®.
An interactive report of the entire dataset to investigate individual VHH antibodies, clonal families, and repertoire-wide features.
Expressed VHH antibodies
1mg of up to 10 antibodies validated by ELISA.
We can work with other species too!
Other Alicanto® Services
Alicanto® uses mass spectrometry combined with next-generation sequencing to identify the highest affinity antibodies that have been selected by the native immune system. Our technology is flexible, and can be applied to a variety of host organisms, including rabbit, human, and llama.
3030 Bunker Hill St #218
San Diego, CA 92109 USA
Publications by Abterra Bio founders and team members include:
- Safonova, et al. (2015). IgRepertoireConstructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis. Bioinformatics, 31, 12:i53-61.
- Cha, SW, Bonissone, S, Na, S, Pevzner, PA, Bafna, V (2017). The Antibody Repertoire of Colorectal Cancer. Mol Cell Proteomics, 16, 12:2111-2124.
- Bonissone, SR, Pevzner, PA (2016). Immunoglobulin Classification Using the Colored Antibody Graph. J Comput Biol, 23, 6:483-94.