Llama Antibody Discovery from Serum

Custom llama antibody discovery using Alicanto®

Directly capture the natural diversity of the immune response
Sequences for all hits delivered!
Over 100 projects completed with Alicanto.
No more panning!

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Key Benefits

More Diverse Hits

By avoiding cloning into phage and panning, Alicanto® directly samples the natural diversity of the llama immune response. This translates to more unique hits for your project.

Higher Hit Rate

We enrich for the desired llama antibodies at the earliest stages of the process, which allows us to avoid wasting time on antibodies that don’t have the desired specificity.

In Vivo Engineering

We deliver all related llama sequences to validated hits which allows you to discover new candidates with potentially different profiles of affinity, immunogenicity, and sequence liabilities.

**We recently analyzed a naive llama repertoire and cover a little more of the biology of llama antibodies in a blog post.

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Llama Antibody Discovery Process

Deliverables

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Sequences

All candidate sequences selected by Alicanto®.

Optional: All VHHs recovered in the repertoire.

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Interactive report

An interactive, web-based report of the entire dataset to investigate individual llama antibodies, clonal families, and repertoire-wide features.

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Expressed llama antibodies

Transient production of antibodies with ELISA binding report.

Other Alicanto® Services

Alicanto® uses mass spectrometry combined with next-generation sequencing to identify the highest affinity antibodies that have been selected by the native immune system. Our technology is flexible, and can be applied to a variety of host organisms, including rabbit, human, and llama.