Griffin: Accessing functional antibodies from serum without B cells
Griffin is a platform for sequencing polyclonal antibodies using mass spectrometry. Since 2009, Abterra Biosciencs founders and employees have been developing novel methods for sequencing antibody proteins directly. Our monoclonal antibody sequencing service, Valens, has been used to successfully sequence hundreds of antibodies without the need for B cells. Now, with Griffin, we can sequencing complex mixes of antibodies directly from patient serum, or from immunized animals.
Watch our CEO, Dr. Natalie Castellana’s presentation on Unlocking the Serum Antibody Repertoire: Accessing Functional Antibodies without B Cells to learn how Griffin works.
Click below to watch the presentation.
Related Posts
VHH De Novo Antibody Sequencing
VHHs are 15kDa proteins that represent the antigen binding portion of heavy chain-only antibodies (HCAb) from llamas and alpacas. Their small size and stability make them ideal components of therapeutics such as bispecific antibodies or CAR-T therapies. In addition,...
Polyclonal Antibody Sequencing in Camelids
Serum contains circulating antibodies with unique functional properties. This fundamental fact is why we choose to mine the serum over cells - despite being more challenging. Here we compare the two approaches for polyclonal antibody sequencing available at Abterra...
Rabbit Polyclonal Antibody Sequencing for Neurodegenerative Disease Research
Rabbit polyclonal antibodies are commonly used reagents across biotech and academia. As of 2024, 43% of commercial catalog antibodies are polyclonals, and 66% of those are rabbit derived. Hyperimmunized rabbits consistently generate high affinity, target-specific...
Get In Touch