De Novo Antibody Sequencing Case Study
Abterra Bio uses bioinformatics and mass spectrometry to reconstructs the full amino acid sequence of both antibody chains. We’ve successfully sequenced human, mouse, rat, hamster, rabbit, and llama antibodies. This approach can be applied across any species and isotype, including IgG’s and IgM’s.
Contact us to learn more about how our Valens™ de novo antibody sequencing can recover the full antibody sequence when no source cell is available!
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For 100% sequence accuracy, antibody sequencing experience matters. Read our blog post to understand more about our service and why you would need de novo sequencing.
Can You Sequence an Antibody?
What does it mean to sequence an antibody?Antibodies are tetrameric proteins comprised of two identical heavy chains and two identical light chains. One naturally occurring exception to this is the heavy chain-only antibodies produced by camelids and cartilaginous...
FASTA2AIRR: comparing human and humanized antibodies
Fasta2airr is a free web app for converting antibody sequences into annotated AIRR-Seq files. Converting sequences into this open format is an essential step in antibody repertoire analysis. Among other antibody meta data the AIRR-Seq file contains: Germline gene...
VHH De Novo Antibody Sequencing
VHHs are 15kDa proteins that represent the antigen binding portion of heavy chain-only antibodies (HCAb) from llamas and alpacas. Their small size and stability make them ideal components of therapeutics such as bispecific antibodies or CAR-T therapies. In addition,...