Protein Sequence Confirmation Service
Are you unsure if your protein sample really is what you think it is? We can help!
Sequence confirmation is a distinct process from our Valens™ de novo protein sequencing service. In sequence confirmation, we have a putative sequence against which to verify the sample. We provide a probability of each amino acid being correct. Read below on different applications of Valens™!
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Applications of Valens™
- Sequence confirmation is a distinct process from de novo sequencing to confirm the translated protein product matches your genetic sequence.
- Identify the translation boundaries and post-translational processing events of your sequence.
Recombinant Protein Confirmation
- Access how well the expressed protein matches the intended gene sequence.
Protein Sequence Confirmation Process
Interactive report with presentation ready image
Peptide coverage of putative protein
Per residue confidence score
Antibody Protein Sequencing Service
Our antibody protein sequencing service can determine the primary amino acid sequence of your monoclonal antibody directly from the protein. Using mass spectrometry together with our patented spectral networking approach, Valens™ recovers full-length amino acid for heavy and light chains.
**Check out our recent blog post that summarizes when to use these de novo antibody sequencing services. Also, read our publication on how we resurrected a clinical antibody.
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Tell Us About Your Project.
Need more information? We’re here to answer any questions you have.
11588 Sorrento Valley Rd
San Diego, CA 92121
Valens builds on over a decade of algorithm development including ideas invented at the University of California – San Diego Center for Computational Mass Spectrometry. For background on our methods check out these publications:
- Guthals, et al. (2012). Shotgun protein sequencing with meta-contig assembly. Mol Cell Proteomics, 11, 10:1084-96.
- Castellana, et al. (2011). Resurrection of a clinical antibody: template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody. Proteomics, 11, 3:395-405.
- Castellana, et al. (2010). Template proteogenomics: sequencing whole proteins using an imperfect database. Mol Cell Proteomics, 9, 6:1260-70.