De Novo Antibody Sequencing Case Study
Abterra Bio uses bioinformatics and mass spectrometry to reconstructs the full amino acid sequence of both antibody chains. We’ve successfully sequenced human, mouse, rat, hamster, rabbit, and llama antibodies. This approach can be applied across any species and isotype, including IgG’s and IgM’s.
Contact us to learn more about how our Valens™ de novo antibody sequencing can recover the full antibody sequence when no source cell is available!
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For 100% sequence accuracy, antibody sequencing experience matters. Read our blog post to understand more about our service and why you would need de novo sequencing.
De Novo Antibody Sequencing NISTmAb with Post-Translational Modification Detection
Protein sequencing has been possible for 75 years with Edman degradation, but over the past decade, mass spectrometry (MS)-based sequencing has become the dominant approach for antibodies. The general strategy is to digest antibody proteins into short peptides using...
Monoclonal versus Polyclonal Antibody Sequencing
Antibody reagents used in biomedical research and diagnostics assays fall into two large categories: monoclonals and polyclonals. For high-quality reagents, an antibody needs to demonstrate specific reactivity in its intended assay, and maintain consistency across...
Polyclonal Antibody Sequencing Methods
Polyclonal Antibody Sequencing Methods Polyclonal antibody sequencing is a powerful tool for understanding the humoral immune response.1 Two primary approaches exist: Proteogenomic Polyclonal Antibody Sequencing and De Novo Polyclonal Antibody Sequencing. This guide...