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PEGS Boston Summit 2021 Presentation

Jun 3, 2021 | News

Next-generation repertoire sequencing for mining single domain antibodies

Abstract:

Next-generation sequencing of antibody repertoires has provided new insights into natural immune responses.  The correlation between the B-cell receptor repertoire and the serological antibody repertoire has only been analyzed in a small number of studies.  In this talk, we will discuss the use of serum antibodies to guide antibody discovery in an immunized llama.  Further, we use next-generation sequencing to mine the clonal lineage of serum-identified antibodies.

We compiled the main key points from the talk into two infographics for a quick read. 

infographic of Alicanto's analysis of llama immune response to immunization
infographic of clonal hit expansion case study

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